Keep an eye on Closely (3)pentobarbital will reduce the level or impact of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Robust or moderate CYP3A4 inducers may improve level of diazepam elimination; for that reason, efficacy of diazepam could be lessened.Barbiturates can induce hepatic microsomal